Sakamaki S, Kohgo Y, Suzuki M, Ogiwara R, Suga T, Kondo N, Izawa M, Kanisawa Y, Niitsu Y
Department of Internal Medicine (Section IV), Sapporo Medical College, Japan.
Int J Immunopharmacol. 1993 Aug;15(6):751-6. doi: 10.1016/0192-0561(93)90148-r.
Effect of in vivo administration of lentinan on IL-6 generation by human peripheral blood monocytes was examined using 5 healthy volunteers. Monocytes isolated from them before and 3 days after intravenous administration of 2 mg lentinan per person were cultured for 2 days and then the levels of IL-6 in the supernatants of cultured monocytes were determined. In vivo lentinan administration elicited an increase in IL-6 generation by monocytes in 3 of 5 cases. Failure to increase IL-6 generation by monocytes in two cases is characteristic of lentinan, since these monocytes generated an apparent level of IL-6 in response to lipopolysaccharide, a potent monocyte activator. Thus, it was demonstrated that lentinan was capable of augmenting IL-6 generation by human monocytes and that there was individual difference in their responsiveness to lentinan.
使用5名健康志愿者研究了体内给予香菇多糖对人外周血单核细胞产生白细胞介素-6（IL-6）的影响。从他们体内分离出单核细胞，在每人静脉注射2mg香菇多糖之前和之后3天进行培养，培养2天后测定培养的单核细胞上清液中IL-6的水平。体内给予香菇多糖使5例中的3例单核细胞产生的IL-6增加。2例单核细胞产生的IL-6未增加是香菇多糖的特征，因为这些单核细胞对强力单核细胞激活剂脂多糖产生了明显水平的IL-6。因此，证明香菇多糖能够增强人单核细胞产生IL-6，并且它们对香菇多糖的反应存在个体差异。
