Fruehauf J P, Bonnard G D, Herberman R B
Immunopharmacology. 1982 Oct;5(1):65-74. doi: 10.1016/0162-3109(82)90037-6.
Activated human monocytes produce a monokine, interleukin-1 (IL-1) which can amplify the immune response by inducing antigen specific T cells to elaborate T cell growth factor, or interleukin-2, which in turn causes T cells to proliferate. The immune adjuvant lentinan has been shown in this study to augment IL-1 production by human monocytes. Stimulation of IL-1 by lentinan was seen as early as 5 hr, with some effect as late as 60 hr. Optimal effects were seen with very low concentrations, around 0.1 micrograms/ml. Lentinan was also able to stimulate IL-1 production by the leukemic cell line, K-562. The data reported here suggest that the previously reported adjuvant effects of lentinan may in part be mediated via its ability to stimulate IL-1 production.
活化的人单核细胞产生一种单核因子，即白细胞介素-1（IL-1），它可通过诱导抗原特异性T细胞产生T细胞生长因子或白细胞介素-2来增强免疫反应，而白细胞介素-2又会促使T细胞增殖。在本研究中已表明免疫佐剂香菇多糖可增强人单核细胞产生IL-1的能力。香菇多糖对IL-1的刺激最早在5小时即可见到，最晚在60小时仍有一定作用。在极低浓度（约0.1微克/毫升）时可观察到最佳效果。香菇多糖还能够刺激白血病细胞系K-562产生IL-1。此处报道的数据表明，先前报道的香菇多糖的佐剂作用可能部分是通过其刺激IL-1产生的能力介导的。
