Davidson Ben, Abeler Vera M
Department of Pathology, The Norwegian Radium Hospital, Oslo.
Diagn Cytopathol. 2005 May;32(5):307-9. doi: 10.1002/dc.20245.
Primary angiosarcoma of the ovary is a rare tumor, with less than 25 cases reported in the literature. These tumors are thought to arise from carcinosarcomas, teratomas or the ovarian vasculature, and occur at any age. The prognosis is dismal in the majority of cases. We present the case of a 19-year old female who presented with abdominal distention and abdominal pain. Tapping of peritoneal effusion showed groups of pleomorphic cells that were negative for epithelial and germ cell markers. Immunohistochemistry performed on the surgical specimen of the ovary, and subsequently on the effusion specimen showed staining for endothelial markers. The patient was treated post-operatively with chemotherapy, but died one year following diagnosis. This is the first reported case of an ovarian angiosarcoma that metastasized to the peritoneal cavity, with a resulting malignant effusion. Despite the rarity of metastasis from gynecological sarcomas in effusions, this possibility needs to be included in the differential diagnosis of malignant effusions that are negative for epithelial and germ cell markers.
原发性卵巢血管肉瘤是一种罕见肿瘤，文献报道的病例不足25例。这些肿瘤被认为起源于癌肉瘤、畸胎瘤或卵巢脉管系统，可发生于任何年龄。大多数病例的预后很差。我们报告一例19岁女性患者，表现为腹胀和腹痛。腹腔积液穿刺显示有一群多形性细胞，上皮和生殖细胞标志物呈阴性。对卵巢手术标本以及随后对积液标本进行免疫组织化学检查，结果显示内皮标志物呈阳性。该患者术后接受化疗，但在诊断后一年死亡。这是首例报告的卵巢血管肉瘤转移至腹腔并导致恶性积液的病例。尽管妇科肉瘤转移至积液非常罕见，但在鉴别诊断上皮和生殖细胞标志物呈阴性的恶性积液时，需要考虑到这种可能性。
