父亲年龄与唐氏综合征。
Paternal age and Down syndrome.
作者信息
Erickson J D
出版信息
Am J Hum Genet. 1979 Jul;31(4):489-97.
The frequency of Down syndrome (DS) in infants of older fathers has been examined in two sets of data. The effect of maternal age was controlled by single years of age. Lack of tight control has been an important weakness of other studies on this subject. Data obtained in metropolitan Atlanta by an intensive case-ascertainment program showed no overall excess of DS infants born to older fathers. Nor was there evidence of such an effect in recent birth certificate data made available by the National Center for Health Statistics. The Atlanta data suggest an increased number of DS infants born to older fathers who had children by women less than or equal to 34 years. However, there was a small deficiency of DS infants born to older fathers by women greater than or equal to 35 years. The possibility of a paternal-age effect remains open, but the available data suggest that, if it exists, it is quite small.
已在两组数据中研究了高龄父亲的婴儿患唐氏综合征（DS）的频率。母亲年龄的影响按单一年龄进行控制。缺乏严格控制是其他关于该主题研究的一个重要弱点。通过强化病例确诊计划在亚特兰大大都市地区获得的数据显示，高龄父亲所生的DS婴儿总体上没有过剩。美国国家卫生统计中心提供的近期出生证明数据中也没有这种影响的证据。亚特兰大的数据表明，年龄较大且其子女母亲年龄小于或等于34岁的父亲所生的DS婴儿数量有所增加。然而，年龄较大且其子女母亲年龄大于或等于35岁的父亲所生的DS婴儿数量略有不足。父亲年龄效应的可能性仍然存在，但现有数据表明，如果存在这种效应，其影响相当小。
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