Miotti P G, Liomba G, Dallabetta G A, Hoover D R, Chiphangwi J D, Saah A J
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
J Infect Dis. 1992 Jun;165(6):1116-9. doi: 10.1093/infdis/165.6.1116.
Flow cytometric studies were done in Malawi on 229 women in their third trimester and 128 women 6 weeks postpartum; both human immunodeficiency virus type 1 (HIV-1)-seropositive and -seronegative women demonstrated an increase in the absolute number of CD4 and CD8 lymphocytes between late pregnancy and early postpartum, while percentages of CD4 and CD8 cells remained virtually unchanged. Subsequent measurement of CD4 and CD8 cells 6 weeks after delivery in 89 women tested in the third trimester showed an increase in absolute numbers in both HIV-1-seropositive and -seronegative women, without a parallel increase in CD4 or CD8 percentage. Regardless of HIV-1 infection status, Malawian women are no more immunosuppressed, as measured by T cells, in their third trimester of pregnancy than in the nonpregnant state. Percentage, rather than absolute number, should be used when monitoring CD4 and CD8 cell levels in pregnant women to avoid the effect of higher volume of distribution on absolute numbers of T cells.
在马拉维，对229名孕晚期妇女和128名产后6周的妇女进行了流式细胞术研究；人类免疫缺陷病毒1型（HIV-1）血清阳性和血清阴性的妇女在妊娠晚期至产后早期，CD4和CD8淋巴细胞的绝对数量均有所增加，而CD4和CD8细胞的百分比基本保持不变。随后，对89名在孕晚期接受检测的妇女在分娩后6周进行的CD4和CD8细胞测量显示，HIV-1血清阳性和血清阴性的妇女的绝对数量均增加，而CD4或CD8百分比并未相应增加。无论HIV-1感染状况如何，通过T细胞测量，马拉维妇女在妊娠晚期的免疫抑制程度并不比非妊娠状态时更高。在监测孕妇的CD4和CD8细胞水平时，应使用百分比而非绝对数量，以避免分布容积增加对T细胞绝对数量的影响。
