马拉维女性中与妊娠及艾滋病毒感染相关的白细胞计数和淋巴细胞亚群
Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.
作者信息
Mandala Wilson L, Gondwe Esther N, Molyneux Malcolm E, MacLennan Jenny M, MacLennan Calman A
机构信息
Malawi-Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi.
Department of Basic Medical Sciences, College of Medicine, Blantyre, Malawi.
出版信息
Am J Reprod Immunol. 2017 Sep;78(3). doi: 10.1111/aji.12678. Epub 2017 Apr 6.
PROBLEM
We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.
METHOD OF STUDY
We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.
RESULTS
Parturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8 T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4 and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy.
CONCLUSION
Malawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.
问题
我们调查了感染或未感染艾滋病毒、怀孕或未怀孕的马拉维女性的白细胞和淋巴细胞亚群，以探究艾滋病毒感染和怀孕是否可能协同作用损害细胞免疫。
研究方法
我们招募了54名怀孕且未感染艾滋病毒的女性、48名未怀孕且未感染艾滋病毒的女性、24名怀孕且感染艾滋病毒的马拉维女性和20名未怀孕且感染艾滋病毒的马拉维女性。我们比较了四组女性外周血白细胞和淋巴细胞亚群。
结果
与未怀孕女性相比，分娩时感染艾滋病毒和未感染艾滋病毒的女性中性粒细胞更多（P均<0.0001），但淋巴细胞更少（P<0.0001；P = 0.0014）。两组的总T细胞（P<0.0001；P = 0.002）和CD8 T细胞（P<0.0001；P = 0.014）均少于未怀孕女性。与未怀孕女性相比，未感染艾滋病毒的分娩期女性的CD4和γδ T细胞、B细胞和NK细胞更少（P均<0.0001）。淋巴细胞亚群百分比不受怀孕影响。
结论
马拉维分娩期女性由于中性粒细胞增多导致白细胞总数增加，且存在与艾滋病毒无关的全淋巴细胞减少。
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