藻酸盐-壳聚糖微胶囊的体外研究：一种用于治疗肝衰竭的肝细胞移植替代方法。
In vitro study of alginate-chitosan microcapsules: an alternative to liver cell transplants for the treatment of liver failure.
作者信息
Haque Tasima, Chen Hongmei, Ouyang Wei, Martoni Christopher, Lawuyi Bisi, Urbanska Aleksandra Malgorzata, Prakash Satya
机构信息
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, Canada H3A 2B4.
出版信息
Biotechnol Lett. 2005 Mar;27(5):317-22. doi: 10.1007/s10529-005-0687-3.
The application of alginate-chitosan (AC) microcapsules to liver cell transplantation has not been previously investigated. In the current in vitro study, we have investigated the potential of AC microcapsules for the encapsulation of liver cells and show that the AC membrane supports the survival, proliferation and protein secretion by entrapped hepatocytes. The AC membrane provides cell immuno-isolation and has the potential for cell cryopreservation. The AC microcapsule has several advantages compared to more widely used alginate-poly-L-lysine (APA) microcapsules for the application of cell therapy.
藻酸盐-壳聚糖（AC）微胶囊在肝细胞移植中的应用此前尚未得到研究。在当前的体外研究中，我们研究了AC微胶囊用于包裹肝细胞的潜力，并表明AC膜支持被包裹肝细胞的存活、增殖和蛋白质分泌。AC膜提供细胞免疫隔离，并且具有细胞冷冻保存的潜力。与更广泛用于细胞治疗的藻酸盐-聚-L-赖氨酸（APA）微胶囊相比，AC微胶囊具有若干优势。
Zotero 插件