用于细胞治疗药物的活细胞微囊化与储存
Microencapsulating and Banking Living Cells for Cell-Based Medicine.
作者信息
Zhang Wujie, He Xiaoming
机构信息
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210.
出版信息
J Healthc Eng. 2011 Dec;2(4):427-446. doi: 10.1260/2040-2295.2.4.427.
Abstract
A major challenge to the eventual success of the emerging cell-based medicine such as tissue engineering, regenerative medicine, and cell transplantation is the limited availability of the desired cell sources. This challenge can be addressed by cell microencapsulation to overcome the undesired immune response (i.e., to achieve immunoisolation) so that non-autologous cells can be used to treat human diseases, and by cell/tissue preservation to bank living cells for wide distribution to end users so that they are readily available when needed in the future. This review summarizes the status quo of research in both cell microencapsulation and banking the microencapsulated cells. It is concluded with a brief outlook of future research directions in this important field.
摘要
诸如组织工程、再生医学和细胞移植等新兴的基于细胞的医学最终取得成功面临的一个主要挑战是所需细胞来源的可用性有限。可以通过细胞微囊化来应对这一挑战，以克服不良免疫反应（即实现免疫隔离），从而能够使用非自体细胞治疗人类疾病；还可以通过细胞/组织保存来储存活细胞，以便广泛分发给终端用户，使其在未来需要时随时可用。本文综述了细胞微囊化和微囊化细胞储存两方面的研究现状，并对这一重要领域未来的研究方向作了简要展望。
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