Hashimoto H, Etani H, Naka M, Kinoshita N, Nukada T
Department of Cardiovascular Medicine, Osaka-Minami National Hospital.
Nihon Ronen Igakkai Zasshi. 1992 Feb;29(2):119-22. doi: 10.3143/geriatrics.29.119.
Transcranial Doppler method (TCD), newly developed in 1982, is ultrasound technology that measures physiologic parameters of blood flow in the major intracranial arteries. A major limitation of TCD is that, in some individuals, satisfactory recording is not possible, especially through the temporal windows. The purpose of the present study is to assess the rate of successful recording in TCD through the temporal ultrasonic windows in Japanese with special reference to aging and sex. In 423 Japanese (244 males and 179 females) aged from 25 to 93 years, measurement of blood flow velocity in basal cerebral arteries was performed by transcranial Doppler velocimeter with a 2 MHz pulsed wave Doppler probe. The signal was successfully recorded in 299 of 423 Japanese (71%). In Japanese males, successful measurement was more frequent (206/244; 84%) than in Japanese females (93/179; 52%). The rate of successful recording was evaluated in every decade from the twenties to the eighties, and it was found to decrease significantly according to age (100%, 94%, 91%, 74%, 66%, 67%, and 46%, respectively). In females, it significantly decreased in those older than 50 years old (100%, 100%, 93%, 61%, 36% 43%, and 27%, respectively), but not in males (100%, 88%, 89%, 81%, 88%, 83%, and 69%, respectively). These findings suggest that this noninvasive method has clinical usefulness for evaluating intracranial circulation but has limitation for assessing the intracranial lesions of elderly Japanese women.
经颅多普勒方法（TCD）于1982年新开发，是一种测量颅内主要动脉血流生理参数的超声技术。TCD的一个主要局限性在于，在某些个体中，无法获得满意的记录，尤其是通过颞窗。本研究的目的是评估在日本人群中通过颞超声窗进行TCD成功记录的比率，并特别参考年龄和性别因素。在423名年龄在25至93岁之间的日本人（244名男性和179名女性）中，使用2MHz脉冲波多普勒探头的经颅多普勒测速仪测量了脑基底动脉的血流速度。在423名日本人中，有299人（71%）成功记录到了信号。在日本男性中，成功测量的频率（206/244；84%）高于日本女性（93/179；52%）。对从二十多岁到八十多岁的每十年的成功记录率进行了评估，发现其随年龄显著下降（分别为100%、94%、91%、74%、66%、67%和46%）。在女性中，50岁以上者的成功率显著下降（分别为100%、100%、93%、61%、36%、43%和27%），但在男性中则没有（分别为100%、88%、89%、81%、88%、83%和69%）。这些发现表明，这种非侵入性方法在评估颅内循环方面具有临床实用性，但在评估老年日本女性的颅内病变方面存在局限性。
