Demirkaya Seref, Uluc Kayihan, Bek Semai, Vural Okay
Department of Neurology, Gülhane Medical School, Ankara, Turkey.
Tohoku J Exp Med. 2008 Feb;214(2):145-9. doi: 10.1620/tjem.214.145.
Transcranial Doppler sonography (TCD) is a non-invasive diagnostic tool enabling evaluation of blood flow characteristics of basal intracerebral vessels via thin calvarian regions. Several factors may affect the normal values of cerebral hemodynamic parameters, and standard reference values for each laboratory are needed for precise interpretation of the results. The aims of this study were to determine normal values of flow velocities of basal cerebral arteries of our TCD laboratory, and to study the influence of age and gender on normal values. We studied 63 healthy volunteers (30 male and 33 females; age range, 5 - 69 years old) with TCD with a 2-MHz transcranial probe. The subjects were divided into 7 age groups: 5-10 years, 11-20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years and > 60 years. Mean velocity (V mean), peak systolic velocity (PSV), and end-diastolic velocities (EDV) were determined in middle, anterior and posterior cerebral arteries. No significant gender difference was found. However, there was a decrease in blood flow velocities in all vessels with advancing age, which was significant when subjects older than 40 years and < or = 40 years old were compared. V mean, PSV and EDV values were highest in the age group of 5 - 10 years old and lowest in volunteers older than the age of 60 (p < 0.05). As a conclusion, flow velocities in basal cerebral arteries range widely and are significantly age-related. Age matching of TCD data is a requirement for clinically relevant conclusions.
经颅多普勒超声检查（TCD）是一种非侵入性诊断工具，可通过颅骨较薄区域评估脑基底血管的血流特征。多种因素可能影响脑血流动力学参数的正常值，为准确解读结果，每个实验室都需要标准参考值。本研究的目的是确定我们TCD实验室脑基底动脉血流速度的正常值，并研究年龄和性别对正常值的影响。我们使用2MHz经颅探头对63名健康志愿者（30名男性和33名女性；年龄范围5 - 69岁）进行了TCD检查。受试者被分为7个年龄组：5 - 10岁、11 - 20岁、21 - 30岁、31 - 40岁、41 - 50岁、51 - 60岁和> 60岁。测定了大脑中动脉、前动脉和后动脉的平均流速（V mean）、收缩期峰值流速（PSV）和舒张末期流速（EDV）。未发现显著的性别差异。然而，随着年龄增长，所有血管的血流速度均下降，40岁及以上与40岁及以下受试者相比差异显著。V mean、PSV和EDV值在5 - 10岁年龄组最高，在60岁以上志愿者中最低（p < 0.05）。结论是，脑基底动脉的血流速度范围广泛且与年龄显著相关。TCD数据的年龄匹配是得出临床相关结论的必要条件。
