Jain Shyama, Nigam Sonu, Kumar Neeta, Reddy B S N
Department of Pathology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
Acta Cytol. 2005 Mar-Apr;49(2):191-4. doi: 10.1159/000326132.
Skin involvement in Hodgkin's disease is rare, can be seen in advanced stages of the disease and indicates a poor prognosis.
A young male presented with multiple nodular lesions on the chest wall and matted cervical lymph nodes. Aspiration smears from skin lesions showed atypical mononuclear cells with a prominent nucleolus, many lymphocytes and plasma cells. Smears from the lymph nodes showed classical Reed-Sternberg cells in a polymorphous background. The cytologic diagnosis of Hodgkin's lymphoma was entertained and later confirmed on skin biopsy. Past history revealed that the patient had been diagnosed with Hodgkin's disease and treated for it 2 years earlier, but had been lost to follow-up during treatment.
Cutaneous Hodgkin's disease should always be considered in smears from skin lesions showing atypical mononuclear cells in a polymorphous background, even in the absence of a definitive clinical diagnosis at the time of presentation.
霍奇金病累及皮肤罕见，可见于疾病晚期，提示预后不良。
一名年轻男性胸壁出现多个结节性病变，颈部淋巴结融合。皮肤病变穿刺涂片显示有明显核仁的非典型单核细胞、许多淋巴细胞和浆细胞。淋巴结涂片在多形性背景中显示经典的里德-施特恩贝格细胞。考虑霍奇金淋巴瘤的细胞学诊断，后经皮肤活检证实。既往史显示患者2年前曾被诊断为霍奇金病并接受治疗，但治疗期间失访。
即使在就诊时没有明确的临床诊断，对于在多形性背景中显示非典型单核细胞的皮肤病变涂片，也应始终考虑皮肤霍奇金病。
