Fay David S
University of Wyoming, College of Agriculture, Department of Molecular Biology, Dept 3944, 1000 E. University Avenue, Laramie, WY 82071, USA.
Semin Cell Dev Biol. 2005 Jun;16(3):397-406. doi: 10.1016/j.semcdb.2005.02.002.
The invariant developmental cell lineage of Caenorhabditis elegans (and other similar nematodes) provides one of the best examples of how cell division patterns can be precisely coordinated with cell fates. Although the field has made substantial progress towards elucidating the many factors that control the acquisition of individual cell or tissue-specific identities, the interplay between these determinants and core regulators of the cell cycle is just beginning to be understood. This review provides an overview of the known mechanisms that govern somatic cell growth, proliferation, and differentiation in C. elegans. In particular, I will focus on those studies that have uncovered novel genes or mechanisms, and which may enhance our understanding of corresponding processes in other organisms.
秀丽隐杆线虫（以及其他类似线虫）不变的发育细胞谱系，为细胞分裂模式如何能与细胞命运精确协调提供了最佳例证之一。尽管该领域在阐明控制个体细胞或组织特异性身份获得的诸多因素方面已取得了重大进展，但这些决定因素与细胞周期核心调节因子之间的相互作用才刚刚开始被理解。本综述概述了秀丽隐杆线虫中控制体细胞生长、增殖和分化的已知机制。特别地，我将聚焦于那些发现了新基因或新机制的研究，这些研究可能会增进我们对其他生物体中相应过程的理解。
