Querol Manuel, Chen John W, Weissleder Ralph, Bogdanov Alexei
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
Org Lett. 2005 Apr 28;7(9):1719-22. doi: 10.1021/ol050208v.
[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.
[反应：见正文] 报道了两种新型二乙三胺五乙酸双酰胺的合成及其一些性质。这些衍生物被设计用作磁共振成像的酶激活造影剂（CA）。两种衍生物都带有酪胺基或5-羟色胺基，在过氧化物酶/H₂O₂对存在的情况下可原位寡聚化，导致纵向（R1）弛豫率净增加。
