Rush D, Orme J, King J, Eiser J R, Butler N R
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Paediatr Perinat Epidemiol. 1992 Apr;6(2):285-97. doi: 10.1111/j.1365-3016.1992.tb00768.x.
Three hundred and forty-six women who reported smoking one or more cigarettes per day prior to the 20th week of gestation were recruited into a trial of health educational counselling to stop or reduce cigarette smoking. Counselling was begun at the first prenatal visit and then continued subsequently in the home. Among the 319 women included in analysis, at first follow-up visit those who received counselling smoked 1.7 fewer cigarettes a day than control women (P less than 0.05) and 10.4% had stopped smoking, compared to 5.4% in the control group (NS). Similar but not significant differences were noted at the end of pregnancy. Study effects were limited to the 284 women smoking five or more cigarettes a day at booking. This report refers primarily to them. At first follow-up visit the proportion of such women in the counselled group who ceased smoking (9.3%) was significantly greater than in the control group (2.6%; P less than 0.05). The magnitude of this difference persisted through late pregnancy (11.8% vs. 4.3%; NS) and delivery (10.6% vs. 4.7%; NS). The differences between counselled women and controls in numbers of cigarettes reported smoked at first and last prenatal follow-up visits (2.4 and 2.1) and at delivery (2.0) were all statistically significant. While there was no effect of counselling on either serum thiocyanate or end expiratory carbon monoxide, the counselled group gained slightly more weight than controls during the study (0.47 vs. 0.44 kg per week among controls; NS), and their infants had modestly higher birthweight (44 g; NS).
346名在妊娠20周前报告每天吸烟1支或更多的女性被纳入一项关于停止或减少吸烟的健康教育咨询试验。咨询在首次产前检查时开始,随后在家庭中继续进行。在纳入分析的319名女性中,在首次随访时,接受咨询的女性每天吸烟比对照组女性少1.7支(P<0.05),10.4%的人已戒烟,而对照组为5.4%(无统计学差异)。在妊娠结束时也发现了类似但无统计学意义的差异。研究效果仅限于在登记时每天吸烟5支或更多的284名女性。本报告主要针对她们。在首次随访时,接受咨询组中此类女性戒烟的比例(9.3%)显著高于对照组(2.6%;P<0.05)。这种差异的幅度在妊娠晚期(11.8%对4.3%;无统计学差异)和分娩时(10.6%对4.7%;无统计学差异)持续存在。在首次和末次产前随访以及分娩时,接受咨询的女性与对照组报告的吸烟支数差异(分别为2.4支、2.1支和2.0支)均具有统计学意义。虽然咨询对血清硫氰酸盐或呼气末一氧化碳均无影响,但在研究期间,接受咨询组的体重增加略多于对照组(对照组每周增加0.44 kg,接受咨询组每周增加0.47 kg;无统计学差异),且她们的婴儿出生体重略高(44 g;无统计学差异)。