Souto E B, Anselmi C, Centini M, Müller R H
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr. 31, D-12169 Berlin, Germany.
Int J Pharm. 2005 May 13;295(1-2):261-8. doi: 10.1016/j.ijpharm.2005.02.005.
Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinity. The chemical stability of n-dodecyl-ferulate at high temperatures was also assessed by thermal gravimetry analysis. For the selection of the appropriated lipid matrix, chemically different lipids were melted with 4% (m/m) of active and lipid nanoparticles were prepared by the so-called high pressure homogenization technique. n-Dodecyl-ferulate-loaded SLN prepared with cetyl palmitate showed the lowest mean particle size and polydispersity index, as well as the highest physical stability during storage time of 21 days at 4, 20 and 40 degrees C. These colloidal dispersions containing the sunscreen also exhibited the common melting behaviour of aqueous SLN dispersions.
开发了含有新型潜在防晒剂阿魏酸正十二烷基酯（阿魏酸的酯）的固体脂质纳米粒（SLN）。研究了负载阿魏酸正十二烷基酯的SLN的制备和稳定性参数，包括粒径、表面电荷（ζ电位）和基质结晶度。还通过热重分析评估了阿魏酸正十二烷基酯在高温下的化学稳定性。为了选择合适的脂质基质，将化学性质不同的脂质与4%（m/m）的活性成分熔融，并通过所谓的高压均质技术制备脂质纳米粒。用棕榈酸十六烷基酯制备的负载阿魏酸正十二烷基酯的SLN在4℃、20℃和40℃下储存21天期间显示出最低的平均粒径和多分散指数，以及最高的物理稳定性。这些含有防晒剂的胶体分散体也表现出水性SLN分散体常见的熔化行为。
