Ramanah R, Martin A, Riethmuller D, Maillet R, Schaal J-P
Service de gynécologie-obstétrique, CHR Saint-Jacques, avenue du 8-Mai-1945, 25030 Besançon cedex, France.
Gynecol Obstet Fertil. 2005 Mar;33(3):107-12. doi: 10.1016/j.gyobfe.2005.01.004.
To evaluate the validity and the feasibility of fetal scalp lactate sampling during labour in the assessment of non reassuring fetal status.
A prospective observational study was conducted on 129 fetal scalp blood samplings. Scalp lactate measurements were compared to scalp pH (gold standard procedure), neonatal cord blood gas (pH and lactates) and Apgar score. Pathological values taken were for scalp lactates>5 mmol/l, scalp pH<7.20, cord arterial pH<7.10, cord arterial lactates>6,35 mmol/l, and Apgar score<7 at one and five minutes. All measurements were performed using the Rapid Lab 860 device from Bayer.
Scalp lactate correlated significantly with scalp pH (R=-0.54, P=0.001), with umbilical artery pH (R=-0.46, P=0,01), with umbilical artery lactate (P=0.49, P=0.01), but with neither Apgar score at one minute (R=-0.21, ns) nor at 5 minutes (R=-0.11, ns). Scalp lactate at a cut-off value of 5 mmol/l had the same predictive values than scalp pH at 7.20 to predict neonatal acidosis. Sampling failure with scalp lactate was inferior to 1 vs 18% for scalp pH.
The measurement of lactate in fetal blood scalp seems correlated to the fetal scalp pH. It may be an attractive alternative to pH analysis and a useful tool for monitoring fetal asphyxia, especially with the advent of handheld devices requiring small sample volumes.
评估分娩期间采集胎儿头皮乳酸样本在评估胎儿窘迫状态时的有效性和可行性。
对129例胎儿头皮血样本进行了一项前瞻性观察研究。将头皮乳酸测量值与头皮pH值(金标准程序)、新生儿脐血气(pH值和乳酸)及阿氏评分进行比较。所采用的病理值为头皮乳酸>5 mmol/L、头皮pH<7.20、脐动脉pH<7.10、脐动脉乳酸>6.35 mmol/L以及1分钟和5分钟时阿氏评分<7。所有测量均使用拜耳公司的Rapid Lab 860设备进行。
头皮乳酸与头皮pH值显著相关(R=-0.54,P=0.001),与脐动脉pH值相关(R=-0.46,P=0.01),与脐动脉乳酸相关(R=0.49,P=0.01),但与1分钟时的阿氏评分(R=-0.21,无显著性差异)及5分钟时的阿氏评分(R=-0.11,无显著性差异)均无相关性。头皮乳酸临界值为5 mmol/L时预测新生儿酸中毒的价值与头皮pH值为7.20时相同。头皮乳酸采样失败率低于头皮pH值,分别为1%和18%。
胎儿头皮血乳酸测量似乎与胎儿头皮pH值相关。它可能是pH分析的一个有吸引力的替代方法,也是监测胎儿窒息的一个有用工具,尤其是随着需要少量样本的手持设备的出现。