Jaskiw G E, Weinberger D R
Clinical Brain Disorders Branch, National Institutes of Mental Health Intramural Research Program, NIMH Research Center, Washington, DC 20032.
Pharmacol Biochem Behav. 1992 Mar;41(3):607-9. doi: 10.1016/0091-3057(92)90380-x.
Locomotor activity of rats with sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC) was assessed after animals were exposed to a 15-min swim or control stress. Swim-stress-induced locomotor activity was augmented in the MPFC-lesioned rats. These and other data suggest that lesions of the MPFC are followed by an exaggeration of the normal behavioral response to stress. Dysregulation of dopamine transmission in the basal ganglia may be involved.
在内侧前额叶皮质（MPFC）接受假手术或鹅膏蕈氨酸损伤的大鼠，在暴露于15分钟游泳或对照应激后，对其运动活动进行评估。游泳应激诱导的运动活动在MPFC损伤的大鼠中增强。这些及其他数据表明，MPFC损伤后，对压力的正常行为反应会被夸大。基底神经节中多巴胺传递的失调可能与之有关。
