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Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat.

作者信息

Jaskiw G E, Weinberger D R

机构信息

Clinical Brain Disorders Branch, NIMH Research Center at St. Elizabeths, Washington, DC 20032.

出版信息

Pharmacol Biochem Behav. 1990 Jul;36(3):695-7. doi: 10.1016/0091-3057(90)90276-n.

DOI:10.1016/0091-3057(90)90276-n
PMID:2377670
Abstract

Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enhanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.

摘要

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