Department of Pharmacology, The University of Pennsylvania School of Medicine, 125 S. 31st Street, Philadelphia, PA, United States.
Behav Brain Res. 2013 Jun 1;246:63-8. doi: 10.1016/j.bbr.2013.02.026. Epub 2013 Mar 1.
Stress elicits relapse to cocaine seeking in humans and in animal models. Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. However, the role of CREB in other stress-induced reinstatement models has not been examined. To determine whether CREB is required across different stressors we examined the ability of restraint to elicit reinstatement of cocaine-conditioned place preference in wild-type and CREBαΔ mutant mice. In contrast to previously published differences in swim stress-induced reinstatement, both wild-type and CREBαΔ mutant mice demonstrated restraint stress elicited reinstatement of cocaine-conditioned reward. While CREB is necessary for swim stress-elicited zif268 expression within the nucleus accubmens (NAc) shell and prelimbic cortex (PrL), restraint-stress-elicited comparable increases in zif268 expression within these regions in both wild-type and CREBαΔ mutant mice. Our findings suggest that not all stressors engage the same circuits or molecular mechanisms to elicit reinstatement behavior.
应激会引起人类和动物模型中可卡因寻求的复发。环磷腺苷反应元件结合蛋白（CREB）是游泳应激诱导可卡因条件性位置偏好复燃所必需的。然而，CREB 在其他应激诱导复燃模型中的作用尚未被研究。为了确定 CREB 是否在不同的应激源中都需要，我们研究了束缚是否能引起野生型和 CREBαΔ 突变小鼠可卡因条件性位置偏好的复燃。与先前发表的游泳应激诱导复燃的差异相反，野生型和 CREBαΔ 突变小鼠都表现出束缚应激引起可卡因条件性奖赏的复燃。虽然 CREB 对于游泳应激诱导的伏隔核（NAc）壳和前额叶皮层（PrL）中的zif268 表达是必需的，但束缚应激在这两个区域引起了野生型和 CREBαΔ 突变小鼠中 zif268 表达的类似增加。我们的研究结果表明，并非所有的应激源都通过相同的回路或分子机制来引起复燃行为。
