Hakaim A G, Stilmant M M, Kauffman J, Schmitt G, Joshi P, Carpinito G, Cho S I
Section of Surgery, Boston Veterans Administration Medical Center, MA.
Am J Kidney Dis. 1992 May;19(5):493-5. doi: 10.1016/s0272-6386(12)80961-9.
In 1987, a patient presented with pulmonary sarcoidosis and progressive renal failure. Percutaneous renal biopsy showed focal glomerular sclerosis (FGS). Over the subsequent 4-year period, her renal failure progressed to require hemodialysis. During this time, her pulmonary sarcoidosis was treated with daily corticosteroid therapy and she remained in clinical remission. The patient received a one-haplotype-identical living-related renal transplant from her mother. The patient is now 25 months posttransplant with a serum creatinine of 106 mumol/L (1.2 mg/dL). Her sarcoidosis continues to be in clinical remission. In this report, we review the rare association of a primary glomerular lesion causing renal failure in patients with sarcoidosis. In addition, we detail the first successful renal transplant in such a patient.
1987年，一名患者出现肺结节病并伴有进行性肾衰竭。经皮肾活检显示局灶性肾小球硬化（FGS）。在随后的4年里，她的肾衰竭进展到需要进行血液透析。在此期间，她的肺结节病接受了每日糖皮质激素治疗，病情保持临床缓解。该患者接受了来自其母亲的单倍型相同的活体亲属肾移植。患者目前移植后25个月，血清肌酐为106 μmol/L（1.2 mg/dL）。她的结节病仍处于临床缓解状态。在本报告中，我们回顾了结节病患者中导致肾衰竭的原发性肾小球病变这一罕见关联。此外，我们详细介绍了此类患者首例成功的肾移植情况。
