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[1989 - 2002年尸检中胎儿及新生儿先天性泌尿系统畸形的谱系]

[The spectrum of congenital malformations of the urinary tract in fetuses and newborns in autopsies in 1989-2002].

作者信息

Czichos Ewa, Kałuzyński Andrzej, Krawczyk Tomasz, Kałuzyńska Anna, Finke Daria, Kulig Andrzej

机构信息

Zaklad Patomorfologii Klinicznej Instytutu Centrum Zdrowia Matki Polki w łodzi.

出版信息

Pol Merkur Lekarski. 2005 Jan;18(103):78-81.

Abstract

The retrospective analysis of own autopsy findings of 831 fetuses and newborns with different forms of congenital malformations were carried out. In 172 cases (20.7%) urinary tract abnormalities were revealed. Isolated malformations represented 43.6% (75 cases) and 56.4% (97 cases) constituted one component of complex multisystem anomalies. Obstructive uropathies with different renal changes represented 54.7% of the isolated malformations, renal agenesis - 28%, autosomal recessive or dominant polycystic renal diseases - 16% and renal hypoplasia 1.3%. Obstructive uropathies were also most prevalent among the multisystem abnormalities (45.4%), while agenesis represented 34% of cases, horseshoe kidney - 12.4%, autosomal polycystic kidney diseases 4.1%, and renal hypoplasia 4.1%. Congenital abnormalities of urinary tract (especially the obstructive uropathies and agenesis) were more common in male fetuses and newborns. A highly frequent coexistence of urinary system congenital abnormalities and malformations of digestive tract, circulatory system and central nervous system were observed.

摘要

对831例患有不同形式先天性畸形的胎儿和新生儿的尸检结果进行了回顾性分析。在172例(20.7%)中发现了泌尿系统异常。孤立性畸形占43.6%(75例),56.4%(97例)构成复杂多系统异常的一个组成部分。伴有不同肾脏改变的梗阻性尿路病占孤立性畸形的54.7%,肾缺如占28%,常染色体隐性或显性多囊肾病占16%,肾发育不全占1.3%。梗阻性尿路病在多系统异常中也最为常见(45.4%),而肾缺如占病例的34%,马蹄肾占12.4%,常染色体多囊肾病占4.1%,肾发育不全占4.1%。泌尿系统先天性异常(尤其是梗阻性尿路病和肾缺如)在男性胎儿和新生儿中更为常见。观察到泌尿系统先天性异常与消化道、循环系统和中枢神经系统畸形高度频繁共存。

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