Ozger Harzem, Eralp Levent, Türker Mehmet, Basaran Mert
Istanbul Tip Fakültesi, Ortopedi ve Travmatoloji Anabilim Dali, 34390 Capa, Istanbul, Turkey.
Int J Clin Oncol. 2005 Apr;10(2):127-32. doi: 10.1007/s10147-004-0470-9.
The current study highlights the clinical features of tumors of the foot and ankle, and presents the clinical outcomes of treatment for 16 patients who were treated at the authors' institution, between 1989 and 1998.
Four tumors occurred in the ankle, three were in the hindfoot, three were in the midfoot, three were in the forefoot, and three were on the plantar surface of the foot. The median duration of symptoms before presentation was 12 months (range, 1-50 months). Fourteen patients were managed by limb-salvage procedures. Three patients were managed by ablative surgery, due to skin, neurovascular, and/or severe bone invasion. In the 9 patients who had wide local resections, local island flaps, split-thickness skin grafts, free vascularized latissimus dorsi flaps, and a free vascularized iliac crest flap were utilized to achieve wound closure.
The patients were followed up for a mean of 74.2 months (range, 48-121 months). The overall survival of the whole group is 71 +/- 3.7 months. Currently, 12 patients are being followed up with no evidence of disease. Of the 14 patients who were managed by limb-salvage procedures, 6 have normal functional status.
Wide resection of malignant tumors of the foot and ankle is considered technically difficult because of technical problems of soft-tissue coverage. However, utilization of local and free flaps provides sufficient closure following wide tumor resection of the foot and ankle, thus yielding satisfactory lower extremity function and local tumor control.
本研究着重介绍足踝部肿瘤的临床特征,并呈现了1989年至1998年间在作者所在机构接受治疗的16例患者的治疗临床结果。
4例肿瘤发生于踝关节,3例在后足,3例在中足,3例在前足,3例在足底。就诊前症状的中位持续时间为12个月(范围1 - 50个月)。14例患者接受保肢手术治疗。3例患者因皮肤、神经血管和/或严重骨侵犯接受了根治性手术。在9例行广泛局部切除的患者中,采用局部岛状皮瓣、中厚皮片移植、游离带血管背阔肌皮瓣和游离带血管髂嵴皮瓣来闭合伤口。
患者平均随访74.2个月(范围48 - 121个月)。全组总体生存期为71±3.7个月。目前,12例患者正在接受随访,无疾病证据。在14例接受保肢手术治疗的患者中,6例功能状态正常。
由于软组织覆盖的技术问题,足踝部恶性肿瘤的广泛切除在技术上被认为是困难的。然而,局部和游离皮瓣的应用为足踝部肿瘤广泛切除后提供了足够的闭合,从而产生令人满意的下肢功能和局部肿瘤控制。