Ulrich Alexis, Z'graggen Kaspar, Weitz Jürgen, Büchler Markus W
Department of General, Visceral and Trauma Surgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
Recent Results Cancer Res. 2005;165:205-11. doi: 10.1007/3-540-27449-9_22.
Within the last 20 years various achievements have been made in the treatment of rectal cancer, improving survival and quality of life of rectal cancer patients. Especially the introduction of the total mesorectal excision (TME) and the use of modern staplers, making anastomoses possible in the deep pelvis, have increased our ability to cure more and more low rectal cancers by sphincter-preserving low anterior resections. Consequently, the interest in functional results after rectal reservoir reconstruction has increased significantly. Various randomized controlled trials have shown that the colon J-pouch (CJP) as a rectal reservoir reconstruction leads to better early functional results compared to the straight coloanal anastomosis (CAA). However, 30% of the patients with CJP faced late evacuation problems, requiring the chronic use of enemas or laxatives. This rate could be decreased to 10% by shortening the limb of the CJP from 8-10 cm to 5-6 cm. The transverse coloplasty pouch (TCP) was developed to provide early functional results comparable to the CJP, while avoiding these late evacuation problems. We report the early postoperative and functional results of 106 patients undergoing low anterior resections with TCP due to rectal cancer between October 2001 and the end of September 2003. Furthermore, we report on a single-center randomized controlled trial to compare the new TCP technique with the gold standard technique of CJP, which we started in October 2002. The objectives were to compare the two pouch reconstruction techniques in terms of morbidity, mortality and functional results.
在过去20年里,直肠癌治疗取得了诸多成就,提高了直肠癌患者的生存率和生活质量。特别是全直肠系膜切除术(TME)的引入以及现代吻合器的使用,使得在骨盆深部进行吻合成为可能,这增强了我们通过保留括约肌的低位前切除术治愈越来越多低位直肠癌的能力。因此,对直肠储袋重建术后功能结果的关注显著增加。多项随机对照试验表明,作为直肠储袋重建方式的结肠J形袋(CJP)与直结肠肛管吻合术(CAA)相比,能带来更好的早期功能结果。然而,30%的CJP患者面临后期排便问题,需要长期使用灌肠剂或泻药。通过将CJP的肠段从8 - 10厘米缩短至5 - 6厘米,这一比例可降至10%。横向结肠成形袋(TCP)的研发旨在提供与CJP相当的早期功能结果,同时避免这些后期排便问题。我们报告了2001年10月至2003年9月底因直肠癌接受TCP低位前切除术的106例患者的术后早期情况和功能结果。此外,我们还报告了一项单中心随机对照试验,该试验于2002年10月开始,旨在将新的TCP技术与CJP的金标准技术进行比较。目的是在发病率、死亡率和功能结果方面比较这两种储袋重建技术。