Ejaz Sohail, Kim Bum Seok, Lim Chae Woong
Biosafety Research Institute, Chonbuk National University, Jeonju, South Korea.
Drug Chem Toxicol. 2005;28(2):245-61. doi: 10.1081/dct-52559.
Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body. Intoxication of sodium bicarbonate (SBC) for 35 days in Korean native broilers was investigated. Sixty birds, aged 2 weeks, divided into 5 groups were exposed to excess SBC: 2 g/L (group A), 7.5 g/L (group B), 20 g/L (group C), 40 g/L (group D). Toxicopathological examination of all exposed birds revealed the manifestation of visceral and articular gout in group C, while birds of group D showed acute kidney damage with manifestation of excessive visceral gout. Interestingly, few birds in group D also showed signs of rare condition of acute articular gout. Dose-dependent increments in erythrocytic count, hematocrit values, and hemoglobin levels of the exposed birds were observed. Hypernatremia, hyperuricemia, hypokalemia, and hypochloremia were common findings among exposed birds. Microscopic examination of birds that manifested visceral gout revealed significant urate deposit, tubular necrosis, and tophi formation in renal interstitium. These findings provide a pathophysiological link that SBC intoxication may support hyperuricemia, which is an independent risk factor for gout and other renal dysfunctions. Further study is required to delineate the effect of lowering uric acid on progression of gout and other renal diseases.
痛风是一种代谢紊乱疾病，会导致高尿酸血症以及正性双折射尿酸钠晶体在身体各部位沉积。研究了韩国本土肉鸡35天的碳酸氢钠（SBC）中毒情况。将60只2周龄的鸡分为5组，使其接触过量的SBC：2 g/L（A组）、7.5 g/L（B组）、20 g/L（C组）、40 g/L（D组）。对所有接触SBC的鸡进行毒理病理学检查发现，C组出现内脏和关节痛风症状，而D组的鸡表现出急性肾损伤并伴有严重的内脏痛风症状。有趣的是，D组中少数鸡还表现出罕见的急性关节痛风症状。观察到接触SBC的鸡的红细胞计数、血细胞比容值和血红蛋白水平呈剂量依赖性增加。高钠血症、高尿酸血症、低钾血症和低氯血症是接触SBC的鸡的常见表现。对出现内脏痛风症状的鸡进行显微镜检查发现，肾间质有明显的尿酸盐沉积、肾小管坏死和痛风石形成。这些发现提供了一个病理生理联系，即SBC中毒可能会加重高尿酸血症，而高尿酸血症是痛风和其他肾脏功能障碍的独立危险因素。需要进一步研究来阐明降低尿酸对痛风和其他肾脏疾病进展的影响。
