Neidel J, Zander D, Hackenbroch M H
Klinik und Poliklinik für Orthopädie, Universität zu Köln, Federal Republic of Germany.
Arch Orthop Trauma Surg. 1992;111(3):171-3. doi: 10.1007/BF00388093.
Perthes' disease was originally viewed as a local ischaemic necrosis of the femoral head. Several authors, however, have presented data suggesting that children with this disease also suffer from a general disorder of skeletal maturation. Hormonal changes in the hypothalamus-pituitary-growth plate axis have been discussed as a possible underlying cause and contradictory results reported on the role of the somatomedins in this process. In this report for the first time sequential data are presented on plasma somatomedin-C (Sm-C/insulin-like growth factor I) levels in 21 boys with Perthes' disease. Values were compared with data from 105 control subjects. The physiologic increase with age of plasma Sm-C levels in the control group was either absent or diminished in children with early-stage Perthes' disease (P less than 10(-6), signs test). The Sm-C values in affected children were low. Our data correlate well with reports from others of retarded skeletal maturation in children with Perthes' disease and support the hypothesis of an accompanying disorder of the synthesis or release of Sm-C/IGF-I or its binding proteins.
佩特兹氏病最初被视为股骨头的局部缺血性坏死。然而，一些作者提出的数据表明，患有这种疾病的儿童也存在骨骼成熟的普遍紊乱。下丘脑 - 垂体 - 生长板轴的激素变化已被讨论为可能的潜在原因，并且关于生长调节素在这一过程中的作用报道了相互矛盾的结果。在本报告中，首次给出了21名患有佩特兹氏病男孩的血浆生长调节素C（Sm-C/胰岛素样生长因子I）水平的系列数据。将这些值与105名对照受试者的数据进行了比较。在早期佩特兹氏病患儿中，对照组血浆Sm-C水平随年龄的生理性升高不存在或减弱（P小于10^(-6)，符号检验）。患病儿童的Sm-C值较低。我们的数据与其他关于佩特兹氏病患儿骨骼成熟延迟的报道密切相关，并支持关于Sm-C/IGF-I或其结合蛋白的合成或释放伴随紊乱的假说。
