Benyacoub J, Pérez P F, Rochat F, Saudan K Y, Reuteler G, Antille N, Humen M, De Antoni G L, Cavadini C, Blum S, Schiffrin E J
Nestlé Research Center, CH-1000, Lausanne 26, Switzerland.
J Nutr. 2005 May;135(5):1171-6. doi: 10.1093/jn/135.5.1171.
We studied the ability of the probiotic organism Enterococcus faecium SF68 to antagonize Giardia intestinalis infection in mice. Oral feeding of E. faecium strain SF68 starting 7 d before inoculation with Giardia trophozoites significantly increased the production of specific anti-Giardia intestinal IgA and blood IgG. This humoral response was mirrored at the cellular level by an increased percentage of CD4(+) T cells in the Peyer's patches and in the spleens of SF68-fed mice. The improvement of specific immune responses in probiotic-fed mice was associated with a diminution in the number of active trophozoites in the small intestine as well as decreased shedding of fecal Giardia antigens (GSA65 protein). The ability of SF68 to stimulate the immune system at both mucosal and systemic levels highlights mechanisms by which this probiotic might antagonize pathogens in vivo. Taken together, the data demonstrate the strong potential of strain SF68 to prevent protozoa from causing intestinal infections.
我们研究了益生菌屎肠球菌SF68拮抗小鼠肠道贾第虫感染的能力。在接种贾第虫滋养体前7天开始口服屎肠球菌SF68菌株，可显著增加特异性抗肠道贾第虫IgA和血液IgG的产生。这种体液反应在细胞水平上表现为，喂食SF68的小鼠派尔集合淋巴结和脾脏中CD4(+) T细胞百分比增加。益生菌喂养小鼠的特异性免疫反应改善与小肠中活跃滋养体数量减少以及粪便中贾第虫抗原（GSA65蛋白）排出减少有关。SF68在黏膜和全身水平刺激免疫系统的能力突出了这种益生菌在体内拮抗病原体的机制。综上所述，数据表明SF68菌株具有强大的潜力来预防原生动物引起的肠道感染。
