Tozon Natasa, Kodre Veronika, Sersa Gregor, Cemazar Maja
University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, SI-1000 Ljubljana, Slovenia.
Anticancer Res. 2005 Mar-Apr;25(2A):839-45.
Electrochemotherapy is an antitumor therapy that utilizes locally-delivered, short intense direct current electric pulse to the tumor nodule plus chemotherapy. The aim of the present study was to evaluate the electrochemotherapy treatment of perianal tumors of different sizes in dogs.
In 12 dogs, 26 tumor nodules of perianal tumors of different size, and clinically expected to be of different histological type, were treated with electrochemotherapy. Electrochemotherapy consisted of intratumoral injection of cisplatin (1 mg/cm3) or bleomycin (3 mg/cm3), followed by application of electric pulses (8 electric pulses; amplitude, 910 V, duration, 100 micros, frequency, 1 Hz) to the tumor nodule.
Responses to treatment were assessed 4 weeks after the therapy; 82% of all tumors treated with electrochemotherapy responded with objective response (OR) (complete response (CR)=41%, partial response (PR)=41%), 16% responded with no change (NC) and 1 tumor (2%) went to progressive disease (PD). At the end of the observation period for each tumor, ranging from 1 to 34 months, 92% OR (CR=65%, PR=27%), 8% NC and no PD were obtained. No major local or general side-effects were noted.
Electrochemotherapy with cisplatin or bleomycin is an effective treatment of perianal tumors in dogs. The advantages of this therapy are its simplicity, short duration of treatment sessions, low chemotherapeutic doses and insignificant side-effects, as well as the fact that the subject does not have to stay in hospital.
电化学疗法是一种抗肿瘤治疗方法，它利用向肿瘤结节局部递送的短时间高强度直流电脉冲并结合化疗。本研究的目的是评估电化学疗法对犬不同大小肛周肿瘤的治疗效果。
对12只犬的26个不同大小、临床预期组织学类型不同的肛周肿瘤结节进行电化学疗法治疗。电化学疗法包括瘤内注射顺铂（1mg/cm³）或博来霉素（3mg/cm³），随后对肿瘤结节施加电脉冲（8个电脉冲；幅度910V，持续时间100微秒，频率1Hz）。
治疗4周后评估治疗反应；接受电化学疗法治疗的所有肿瘤中，82%出现客观反应（OR）（完全缓解（CR）=41%，部分缓解（PR）=41%），16%无变化（NC），1个肿瘤（2%）进展为疾病进展（PD）。在每个肿瘤1至34个月的观察期结束时，获得了92%的OR（CR=65%，PR=27%），8%为NC，无PD。未观察到严重的局部或全身副作用。
顺铂或博来霉素电化学疗法是治疗犬肛周肿瘤的有效方法。该疗法的优点包括操作简单、治疗疗程短、化疗剂量低、副作用不明显，以及动物无需住院。
