Spugnini Enrico P, Vincenzi Bruno, Baldi Feliciano, Citro Gennaro, Baldi Alfonso
S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy.
Anticancer Res. 2006 Nov-Dec;26(6B):4585-9.
Electrochemotherapy (ECT) is a novel anticancer therapy that combines the delivery of trains of appropriate waveforms with the local administration of chemotherapy agents. The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT).
Twenty-eight privately-owned dogs with incompletely removed MCT were treated with intralesional bleomycin (1.5 IU/cm2) followed by the application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50 + 50 micros duration, 1 Hz frequency).
The overall response rate was 85% with a mean estimated time to recurrence of 52.76 +/- 6.5 months (range: 39.99 to 65.54 months, 95% CI). At the time of writing this report, the median survival time was not reached. Three dogs died of metastatic disease that they developed at the same time of local recurrence, one developed multiple cutaneous nodules at different locations and one with recurrence was re-treated and is currently disease-free after 22 months. No major local or systemic toxicities were noted for the duration of the study.
ECT is a safe and effective therapy for incompletely excised MCTs in companion animals. Its ease of administration, lack of toxicities and low cost make it an attractive alternative to standard treatments and warrants further investigation.
电化学疗法（ECT）是一种新型抗癌疗法，它将适当波形的电脉冲传递与化疗药物的局部给药相结合。本研究的目的是评估ECT对治疗切除不完全的肥大细胞瘤（MCT）的辅助潜力。
28只患有切除不完全的MCT的宠物犬接受了瘤内注射博来霉素（1.5 IU/cm²），随后施加双相脉冲序列（8个脉冲，1300 V/cm，50 + 50微秒持续时间，1 Hz频率）。
总体缓解率为85%，平均估计复发时间为52.76 +/- 6.5个月（范围：39.99至65.54个月，95%置信区间）。在撰写本报告时，中位生存时间尚未达到。3只犬死于局部复发时同时发生的转移性疾病，1只犬在不同部位出现多个皮肤结节，1只复发犬接受了再次治疗，目前在22个月后无疾病。在研究期间未观察到重大的局部或全身毒性。
ECT是治疗伴侣动物切除不完全的MCT的一种安全有效的疗法。其给药简便、无毒性且成本低，使其成为标准治疗的有吸引力的替代方法，值得进一步研究。
