健康效应分类及其在最低风险水平推导中的作用：肝脏效应

Health effects classification and its role in the derivation of minimal risk levels: hepatic effects.

作者信息

Pohl Hana R, Chou C-H Selene J

机构信息

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.

出版信息

Regul Toxicol Pharmacol. 2005 Jul;42(2):161-71. doi: 10.1016/j.yrtph.2005.03.002.

DOI:10.1016/j.yrtph.2005.03.002

PMID:15869832

Abstract

The Agency for Toxic Substances and Disease Registry (ATSDR) derives health based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. Current MRLs are posted on ATSDR's web site (www.atsdr.cdc.gov). From the total 326 MRLs currently posted, 79 MRLs are based on hepatic endpoints. The paper reports on endpoints used for the derivation of these MRLs and the use of uncertainty factors. It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles.

摘要

有毒物质与疾病登记署（ATSDR）制定了基于健康的指导值，即最低风险水平（MRLs），以协助评估接触有害化学物质所带来的风险。当前的MRLs发布在ATSDR的网站（www.atsdr.cdc.gov）上。在目前发布的总共326个MRLs中，有79个MRLs是基于肝脏终点指标得出的。本文报告了用于推导这些MRLs的终点指标以及不确定性系数的使用情况。它还描述了如ATSDR《毒理学概况编制指南》中所述的将效应分为不太严重和严重两类的分级情况。