Pohl H R, Smith-Simon C, Hicks H
Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
Regul Toxicol Pharmacol. 1998 Aug;28(1):55-60. doi: 10.1006/rtph.1998.1232.
Agency for Toxic Substances and Disease Registry (ATSDR) utilizes chemical-specific minimal risk levels (MRLs) to assist in evaluating the public health risk associated with exposure to hazardous substances. The MRLs are derived based on the health effects data compiled from current literature searches and presented in ATSDR's toxicological profiles. Health effects are categorized according to their degree of severity (e.g., serious, less serious, minimal, and not adverse). This evaluation is important, because each respective category can be assigned a different amount of uncertainty, thus affecting the final value of the calculated MRL. From the total of 272 MRLs derived as of December 1997, 21 were based on developmental effects. ATSDR's ranking of developmental health effects as described in the Guidance for Developing Toxicological Profiles and specific examples of how the categorized health effects were used in MRL derivations are provided in this paper.
有毒物质与疾病登记署（ATSDR）利用化学物质特异性最小风险水平（MRLs）来协助评估与接触有害物质相关的公共健康风险。MRLs是根据从当前文献检索中汇编并在ATSDR毒理学概况中呈现的健康影响数据得出的。健康影响根据其严重程度进行分类（例如，严重、较不严重、最小和无不良影响）。这种评估很重要，因为每个相应类别可被赋予不同程度的不确定性，从而影响计算得出的MRL的最终值。截至1997年12月得出的272个MRLs中，有21个基于发育影响。本文提供了ATSDR在《毒理学概况编制指南》中对发育健康影响的排名，以及分类健康影响在MRL推导中如何使用的具体示例。
