Abadin H G, Murray H E, Wheeler J S
Division of Toxicology, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA.
Regul Toxicol Pharmacol. 1998 Aug;28(1):61-6. doi: 10.1006/rtph.1998.1238.
The Agency for Toxic Substances and Disease Registry (ATSDR) derives minimal risk levels (MRLs) to assist in evaluating risk of adverse health effects in individuals exposed to hazardous substances. MRLs are derived from published values identifying no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOAELs) in animal or human studies. The most sensitive end points are used. To date, 4 inhalation MRLs and 13 oral MRLs have been derived from hematological end points for 12 substances. This paper provides a brief overview of the hematological system, examples of hematological end points, and the MRL for substances with hematological end points.
有毒物质与疾病登记署（ATSDR）制定最低风险水平（MRLs），以协助评估接触有害物质的个体产生不良健康影响的风险。MRLs源自已发表的动物或人体研究中确定的未观察到有害作用水平（NOAELs）或最低观察到有害作用水平（LOAELs）的值。使用最敏感的终点。迄今为止，已从12种物质的血液学终点得出4个吸入MRLs和13个口服MRLs。本文简要概述了血液系统、血液学终点的示例以及具有血液学终点的物质的MRL。
