Watari Jiro, Saitoh Yusuke, Fujiya Mikihiro, Nakamura Kazumasa, Inaba Yuhei, Okamoto Kotaro, Tanabe Hiroki, Yasuda Atsumi, Miyokawa Naoyuki, Kohgo Yutaka
Third Department of Internal Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa 078-8510, Japan.
J Gastroenterol. 2005 Apr;40(4):414-20. doi: 10.1007/s00535-004-1561-0.
Spontaneous and complete disappearance of diffuse large B-cell lymphoma (DLBL) of the stomach is extremely rare. Although regression of gastric DLBL after eradication of Helicobacter pylori has recently been reported, we present two consecutive cases of stage I DLBL of the stomach which disappeared after only nonspecific therapy, including histamine 2-receptor antagonist (H2RA); both cases were documented histologically and endoscopically. Both patients were positive for H. pylori, and later received H. pylori eradication therapy. The disease has not recurred after 11 and 6 months, respectively. Our cases suggest that the option of combination therapy with H2RA either with or followed by H. pylori eradication is appropriate for consideration as an initial approach in standard therapy for stage I diffuse large B-cell gastric lymphoma.
胃弥漫性大B细胞淋巴瘤（DLBL）自发完全消失极为罕见。尽管最近有报道称幽门螺杆菌根除后胃DLBL有所消退，但我们报告了两例连续的I期胃DLBL病例，仅经过非特异性治疗（包括组胺2受体拮抗剂（H2RA））后就消失了；两例均有组织学和内镜记录。两名患者幽门螺杆菌均呈阳性，随后接受了幽门螺杆菌根除治疗。分别在11个月和6个月后疾病未复发。我们的病例表明，H2RA联合治疗（无论是否在幽门螺杆菌根除治疗之前或之后）作为I期弥漫性大B细胞胃淋巴瘤标准治疗的初始方法值得考虑。
