Schropp C, Sörensen N, Collmann H, Krauss J
University Children's Hospital Wuerzburg, Josef-Schneider-Strasse 2, 97080, Würzburg, Germany.
Childs Nerv Syst. 2006 Feb;22(2):125-31. doi: 10.1007/s00381-005-1150-4. Epub 2005 May 4.
This study was conducted to investigate the frequency and type of cutaneous stigmata in different forms of occult spinal dysraphism (OSD) and their correlation to the underlying malformation.
Fourteen different forms of spinal malformations were identified in 358 operated patients with OSD. Most frequent findings (isolated or in combinations) were spinal lipoma, split cord malformation, pathologic filum terminale, dermal sinus, meningocele manqué, myelocystocele and caudal regression. Stigmata were present in 86.3% of patients, often in various combinations. Using a binary logistic regression analysis, significant correlations with distinct malformations were found for subcutaneous lipomas, skin tags, vascular nevi, pori, hairy patches, hypertrichosis, meningoceles and "cigarette burn" marks.
Cutaneous markers in a high percentage accompany spinal malformations. Due to the correlations of different stigmata to distinct malformations, they can aid the clinician in further diagnostic and therapeutic work.
本研究旨在调查不同形式隐性脊柱裂（OSD）中皮肤体征的频率和类型，以及它们与潜在畸形的相关性。
在358例接受手术的OSD患者中识别出14种不同形式的脊柱畸形。最常见的发现（单独或合并出现）为脊髓脂肪瘤、脊髓纵裂畸形、终丝异常、皮样窦、隐性脊膜膨出、脊髓脊膜囊肿和尾椎退化。86.3%的患者存在体征，且常为多种体征合并出现。通过二元逻辑回归分析，发现皮下脂肪瘤、皮肤赘生物、血管痣、小孔、毛斑、多毛症、脊膜膨出和“烟头烫伤”痕迹与特定畸形存在显著相关性。
高比例的皮肤标志物与脊柱畸形同时存在。由于不同体征与特定畸形之间存在相关性，它们可协助临床医生进行进一步的诊断和治疗工作。
