Doyle P, Beral V, Maconochie N
Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
Hum Reprod. 1992 Mar;7(3):425-8. doi: 10.1093/oxfordjournals.humrep.a137663.
The Medical Research Council In-Vitro Fertilization (IVF) Register report on births resulting from assisted conception in Great Britain demonstrated a high incidence of preterm and low birthweight babies. This incidence remained high even when the analysis was restricted to singleton babies. The present paper investigates possible risk factors for prematurity, low birthweight and small-for-gestational-age (SGA) in singleton IVF births. Thirteen per cent of singleton IVF babies were preterm, 11% low birthweight and 17% small-for-gestational-age. Analysis by multiple regression indicated that hypertension during pregnancy was an independent risk for preterm delivery, low birthweight and SGA, bleeding during pregnancy for preterm delivery, and the number of embryos transferred and the type of infertility for low birthweight.
医学研究委员会体外受精（IVF）登记处关于英国辅助受孕所生孩子的报告显示，早产和低体重儿的发生率很高。即使将分析仅限于单胎婴儿，这一发生率仍然很高。本文调查了单胎体外受精出生儿早产、低体重和小于胎龄（SGA）的可能风险因素。13%的单胎体外受精婴儿为早产，11%为低体重，17%为小于胎龄。多元回归分析表明，孕期高血压是早产、低体重和小于胎龄的独立风险因素，孕期出血是早产的风险因素，移植胚胎数量和不孕类型是低体重的风险因素。
