Section of Reproductive Endocrinology and Infertility, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.
Fertil Steril. 2013 Feb;99(2):303-10. doi: 10.1016/j.fertnstert.2012.12.035.
Since 1978, we have witnessed a successful evolution of assisted reproductive technology (ART), with improvement of the pregnancy rates and a growing demand. However, in recent years, there has been increasing concern regarding its safety due to the potential health impact on its infants. The raise of the developmental origins of adult disease has positioned low birth weight (LBW) as a significant health issue. Although multiple studies have associated ART with LBW, the etiology of this association remains largely unknown. We review the potential association between different components of ART and infertility with LBW, while acknowledging the limitations of interpretation of the existing literature.
自 1978 年以来，辅助生殖技术（ART）取得了成功的发展，妊娠率提高，需求不断增长。然而，近年来，由于其对婴儿潜在的健康影响，人们越来越关注其安全性。成人疾病的发育起源问题使低出生体重（LBW）成为一个重大的健康问题。尽管多项研究表明 ART 与 LBW 有关，但这种关联的病因仍很大程度上未知。我们回顾了 ART 的不同组成部分和不孕与 LBW 之间的潜在关联，同时认识到对现有文献的解释存在局限性。
