Department of ENT Head and Neck Surgery, Odense University Hospital, Denmark.
Oral Oncol. 2011 Jul;47(7):677-82. doi: 10.1016/j.oraloncology.2011.04.020. Epub 2011 May 25.
To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.
描述丹麦唾液腺癌的发病率、部位和组织学（2005 年 WHO）。从三个全国性登记处确定了 1990 年至 2005 年期间诊断的 983 名患者。从患者病历中回顾性检索相关临床数据。对 886 例（90%）进行了组织学复查。基于组织学复查，31 例患者（3%）被排除在研究之外，952 例患者用于流行病学分析。丹麦的粗发病率平均值为 1.1/100,000/年。男女比例为 0.97，中位年龄为 62 岁。腮腺是最常见的部位（52.5%），其次是口腔小唾液腺（26.3%）。最常见的组织学亚型是腺样囊性癌（25.2%）、黏液表皮样癌（16.9%）、非特异性腺癌（12.2%）和腺泡细胞癌（10.2%）。在 886 例中，有 121 例（14%）经复查改变了组织学诊断。丹麦唾液腺癌的发病率高于以往报道。超过一半的唾液腺癌位于腮腺，最常见的亚型是腺样囊性癌。唾液腺癌的组织学分类较为困难，由专门的病理专家进行评估可能对最佳诊断和治疗至关重要。
