巯基尿酸作为职业毒理学中接触活性化学物质的生物标志物再探讨：一篇综述。
Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview.
作者信息
Haufroid V, Lison D
机构信息
Université catholique de Louvain, Unité de Toxicologie Industrielle et Environnementale, Clos Chapelle-aux-Champs 30 boite 54, 1200 Bruxelles, Belgium.
出版信息
Int Arch Occup Environ Health. 2005 Jun;78(5):343-54. doi: 10.1007/s00420-005-0620-z. Epub 2005 May 10.
A minireview is presented concerning the use of mercapturic acids as biological exposure index for electrophilic chemicals. Besides pure analytical aspects, this minireview considers possible issues in relation to (a) the added value of mercapturic acids as compared to other well validated biomarkers of exposure and (b) the high inter-individual variability in mercapturic acids excretion. Recent field and/or experimental studies confirm the usefulness of mercapturic acids as biological exposure index for electrophilic chemicals and suggest the interest of a toxicogenetic approach for a better interpretation of the results of biological monitoring.
本文给出一篇关于使用硫醚氨酸作为亲电化学物质生物暴露指标的综述。除了纯分析方面，该综述还考虑了与以下方面相关的可能问题：（a）与其他经过充分验证的暴露生物标志物相比，硫醚氨酸的附加值；（b）硫醚氨酸排泄的个体间高变异性。最近的现场和/或实验研究证实了硫醚氨酸作为亲电化学物质生物暴露指标的有用性，并表明采用毒理遗传学方法有助于更好地解释生物监测结果。
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