近期蓝藻生物钟蛋白结构表明存在一个旋转时钟。

Recent cyanobacterial Kai protein structures suggest a rotary clock.

作者信息

Wang Jimin

机构信息

Department of Molecular Biophysics and Biochemistry, Center for Structural Biology, Yale University, New Haven, Connecticut 06520-8114, USA.

出版信息

Structure. 2005 May;13(5):735-41. doi: 10.1016/j.str.2005.02.011.

DOI:10.1016/j.str.2005.02.011

PMID:15893664

Abstract

The cyanobacterial circadian oscillator consists of three Kai proteins, KaiA, KaiB, and KaiC, in its oscillation feedback loop. Structural comparison reveals that the Kai system resembles the F1-ATPase system in which KaiC is equivalent to alpha(3)beta(3), KaiA to gammadelta, and KaiB to its inhibitory factor. It also suggests that there exists a possible haemagglutinin-like spring-loaded mechanism for the activation of KaiA during the formation of Kai complexes.

摘要

蓝藻生物钟振荡器在其振荡反馈回路中由三种Kai蛋白（KaiA、KaiB和KaiC）组成。结构比较显示，Kai系统类似于F1 - ATP酶系统，其中KaiC相当于α(3)β(3)，KaiA相当于γδ，KaiB相当于其抑制因子。这也表明在Kai复合物形成过程中，可能存在一种类似血凝素的弹簧加载机制来激活KaiA。