腺苷的心脏保护作用：“一个包裹在谜团中的谜题”。
Cardioprotection with adenosine: 'a riddle wrapped in a mystery'.
作者信息
Przyklenk Karin, Whittaker Peter
机构信息
Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
出版信息
Br J Pharmacol. 2005 Jul;145(6):699-700. doi: 10.1038/sj.bjp.0706261.
Abstract
Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.
摘要
回顾已发表的关于腺苷与心脏保护作用的文献，可能会让人套用温斯顿·丘吉尔爵士（1939年10月1日广播讲话（关于俄罗斯））的名言并得出结论：“我无法向你们预测腺苷的作用。它是一个包裹在谜团中的谜，谜中还有谜”。也就是说，尽管腺苷能够使心肌细胞对致死性缺血/再灌注诱导的损伤产生抗性这一点已得到充分证实，但关于腺苷限制心肌梗死面积的机制，仍不断有新的、引人入胜的见解出现。
相似文献
1
Cardioprotection with adenosine: 'a riddle wrapped in a mystery'.腺苷的心脏保护作用：“一个包裹在谜团中的谜题”。
Br J Pharmacol. 2005 Jul;145(6):699-700. doi: 10.1038/sj.bjp.0706261.
2
New insights into adenosine-mediated myocardial protection.腺苷介导的心肌保护新见解。
Br J Pharmacol. 2005 Jul;145(6):701-2. doi: 10.1038/sj.bjp.0706262.
3
4
Intravenous adenosine protects the myocardium primarily by activation of a neurogenic pathway.静脉注射腺苷主要通过激活神经源性途径来保护心肌。
Br J Pharmacol. 2005 Jul;145(6):703-11. doi: 10.1038/sj.bjp.0706258.
5
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.川芎嗪对大鼠心肌缺血再灌注损伤的保护作用：内皮型一氧化氮合酶的作用。
Clin Exp Pharmacol Physiol. 2012 Jan;39(1):20-7. doi: 10.1111/j.1440-1681.2011.05628.x.
6
Preconditioning with acute and chronic lithium administration reduces ischemia/reperfusion injury mediated by cyclooxygenase not nitric oxide synthase pathway in isolated rat heart.急性和慢性给予锂进行预处理可减轻离体大鼠心脏中由环氧化酶而非一氧化氮合酶途径介导的缺血/再灌注损伤。
Eur J Pharmacol. 2008 Nov 12;597(1-3):57-63. doi: 10.1016/j.ejphar.2008.08.010. Epub 2008 Aug 22.
7
[Cardioprotection of adenosine treatment in cadaver donor rats with warm ischemia].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Aug;35(8):885-91. doi: 10.3969/j.issn.1672-7347.2010.08.019.
8
Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.腺嘌呤核苷 A1 受体的激活可恢复高同型半胱氨酸血症大鼠心脏中缺血预处理抑制的心脏保护作用。
J Cardiovasc Pharmacol. 2009 Sep;54(3):204-12. doi: 10.1097/FJC.0b013e3181b04cc5.
9
Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury.延迟24小时注射N-硝基-L-精氨酸甲酯可诱导对再灌注损伤的药理学心脏保护作用。
Cell Mol Biol (Noisy-le-grand). 2007 Jan 21;52 Suppl:OL868-73.
10
Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs.再灌注时腺苷治疗对犬心肌梗死面积的影响。
Cardiovasc Res. 1996 May;31(5):711-8. doi: 10.1016/0008-6363(95)00235-9.
引用本文的文献
1
Repeated Remote Ischemic Conditioning Effect on Ankle-brachial Index in Diabetic Patients - A Randomized Control Trial.重复远程缺血预处理对糖尿病患者踝臂指数的影响——一项随机对照试验
Adv Biomed Res. 2017 Mar 7;6:28. doi: 10.4103/2277-9175.201685. eCollection 2017.
2
Cardiac purinergic signalling in health and disease.健康与疾病中的心脏嘌呤能信号传导
Purinergic Signal. 2015 Mar;11(1):1-46. doi: 10.1007/s11302-014-9436-1. Epub 2014 Dec 20.
3
Remote ischemic preconditioning in patients with intermittent claudication.间歇性跛行患者的远程缺血预处理。
Clinics (Sao Paulo). 2013 Apr;68(4):495-9. doi: 10.6061/clinics/2013(04)10.
4
Adenosine kinase: exploitation for therapeutic gain.腺嘌呤激酶：为治疗增益而进行的开发。
Pharmacol Rev. 2013 Apr 16;65(3):906-43. doi: 10.1124/pr.112.006361. Print 2013 Jul.
本文引用的文献
1
Intravenous adenosine protects the myocardium primarily by activation of a neurogenic pathway.静脉注射腺苷主要通过激活神经源性途径来保护心肌。
Br J Pharmacol. 2005 Jul;145(6):703-11. doi: 10.1038/sj.bjp.0706258.
2
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes.腺苷可产生一氧化氮并预防大鼠心肌细胞中的线粒体氧化损伤。
Cardiovasc Res. 2005 Mar 1;65(4):803-12. doi: 10.1016/j.cardiores.2004.12.004.
3
Preconditioning the myocardium: from cellular physiology to clinical cardiology.心肌预处理：从细胞生理学到临床心脏病学
Physiol Rev. 2003 Oct;83(4):1113-51. doi: 10.1152/physrev.00009.2003.
4
Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning.“框外”心脏保护——远程预处理的不断演变范式
Basic Res Cardiol. 2003 May;98(3):149-57. doi: 10.1007/s00395-003-0406-y.
5
Sites of action of adenosine in interorgan preconditioning of the heart.腺苷在心脏器官间预处理中的作用位点。
Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H29-37. doi: 10.1152/ajpheart.01031.2001.
6
Limitation of infarct size in rabbit hearts by the novel adenosine receptor agonist AMP 579 administered at reperfusion.在再灌注时给予新型腺苷受体激动剂AMP 579对兔心脏梗死面积的限制作用
J Mol Cell Cardiol. 2000 Dec;32(12):2339-47. doi: 10.1006/jmcc.2000.1264.
7
Comparison of interstitial fluid and coronary venous adenosine levels in in vivo porcine myocardium.
J Mol Cell Cardiol. 1998 Jun;30(6):1137-47. doi: 10.1006/jmcc.1998.0683.
8
Ischemic preconditioning: exploring the paradox.缺血预处理：探索这一悖论。
Prog Cardiovasc Dis. 1998 May-Jun;40(6):517-47. doi: 10.1016/s0033-0620(98)80002-9.
9
Myocardial protection by brief ischemia in noncardiac tissue.非心脏组织短暂缺血对心肌的保护作用。
Circulation. 1996 Nov 1;94(9):2193-200. doi: 10.1161/01.cir.94.9.2193.
10
Intramyocardial injections and protection against myocardial ischemia. An attempt to examine the cardioprotective actions of adenosine.
Circulation. 1996 Jun 1;93(11):2043-57. doi: 10.1161/01.cir.93.11.2043.
Zotero 插件