Durodoye Oluyemisi M, Mendlovic Daniel B, Brenner Robert S, Morrow Jay S
Department of Internal Medicine, Huron Hospital, Cleveland Clinic Health System, Cleveland, Ohio, USA.
Endocr Pract. 2005 Mar-Apr;11(2):120-4. doi: 10.4158/EP.11.2.120.
To report 5 cases of empty sella syndrome (ESS) manifesting with various degrees of pituitary dysfunction.
We describe the initial manifestations in 5 patients with primary ESS and in previous cases of ESS reported in the English language literature.
Review of our recent medical records identified 5 patients referred for evaluation of pituitary deficiencies in whom ESS was diagnosed. Glucocorticoid replacement was required in 3 patients, 2 of whom presented initially with symptoms of severe glucocorticoid deficiency. In each case, magnetic resonance imaging of the brain demonstrated an empty sella.
Our cases suggest that endocrine abnormalities are not rare as the initial manifestation of ESS and that, contrary to many studies in the literature, the endocrine abnormalities may be quite severe.
报告5例表现为不同程度垂体功能障碍的空蝶鞍综合征（ESS）。
我们描述了5例原发性ESS患者的初始表现以及英文文献中先前报道的ESS病例。
回顾我们最近的病历发现，5例因垂体功能减退前来评估的患者被诊断为ESS。3例患者需要糖皮质激素替代治疗，其中2例最初表现为严重糖皮质激素缺乏症状。在每例病例中，脑部磁共振成像均显示为空蝶鞍。
我们的病例表明，内分泌异常作为ESS的初始表现并不罕见，而且与文献中的许多研究相反，内分泌异常可能相当严重。
