Taroni Paola, Torricelli Alessandro, Spinelli Lorenzo, Pifferi Antonio, Arpaia Francesco, Danesini Gianmaria, Cubeddu Rinaldo
INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy.
Phys Med Biol. 2005 Jun 7;50(11):2469-88. doi: 10.1088/0031-9155/50/11/003. Epub 2005 May 18.
The first time-resolved optical mammograph operating beyond 900 nm was tested in a retrospective clinical study involving 194 patients with malignant and benign lesions, to investigate the diagnostic potential for the detection and characterization of breast lesions. For the first part of the study (101 patients with 114 lesions), the system was operated at 683, 785, 913 and 975 nm. Subsequently, to improve the spectral content of optical images, the number of wavelengths was increased (up to 7) and the spectral range was extended (637-985 nm). Late gated intensity and scattering images provide sensitivity to tissue composition (oxy- and deoxyhaemoglobin, water and lipids) and physiology (total haemoglobin content and oxygen saturation), as well as to structural changes. Tumours are typically identified because of the strong blood absorption at short wavelengths (637-685 nm), while cysts are characterized by low scattering, leading to a detection rate of approximately 80% for both lesion types, when detection is required in both cranio-caudal and oblique views. The detection rate for other benign lesions, such as fibroadenomas, is presently much lower (<40%). The effectiveness of the technique in localizing and identifying different lesion types was analysed as a function of various parameters (lesion size, compressed breast thickness, age, body mass index, breast parenchymal pattern). The possibility that physiologic changes due to the development of a malignant lesion could affect the entire breast was investigated. The capacity to assess the density of breast based on the average scattering properties was also tested.
首款工作波长超过900 nm的时间分辨光学乳腺成像仪在一项回顾性临床研究中进行了测试，该研究涉及194例患有恶性和良性病变的患者，旨在探究其对乳腺病变的检测及特征描述的诊断潜力。在研究的第一部分（101例患者，114个病变）中，该系统在683、785、913和975 nm波长下运行。随后，为了提高光学图像的光谱含量，增加了波长数量（最多7个）并扩展了光谱范围（637 - 985 nm）。晚期选通强度和散射图像对组织成分（氧合血红蛋白和脱氧血红蛋白、水和脂质）、生理状态（总血红蛋白含量和氧饱和度）以及结构变化具有敏感性。肿瘤通常因在短波长（637 - 685 nm）下有强烈的血液吸收而被识别，而囊肿的特征是低散射，当需要在头尾位和斜位视图中进行检测时，两种病变类型的检测率约为80%。其他良性病变（如纤维腺瘤）的检测率目前要低得多（<40%）。分析了该技术在定位和识别不同病变类型方面的有效性与各种参数（病变大小、乳腺压缩厚度、年龄、体重指数、乳腺实质类型）的关系。研究了恶性病变发展引起的生理变化可能影响整个乳腺的可能性。还测试了基于平均散射特性评估乳腺密度的能力。
