Yates Tara, Hebden Jeremy C, Gibson Adam, Everdell Nick, Arridge Simon R, Douek Michael
Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
Phys Med Biol. 2005 Jun 7;50(11):2503-17. doi: 10.1088/0031-9155/50/11/005. Epub 2005 May 18.
A time-resolved optical tomography system has been used to generate cross-sectional images of the human breast. Images are reconstructed using an iterative, nonlinear algorithm and measurements of mean photon flight time relative to those acquired on a homogeneous reference phantom. Thirty-eight studies have been performed on three healthy volunteers and 21 patients with a variety of breast lesions including cancer. We have successfully detected 17 out of 19 lesions, and shown that optical images of the healthy breast of the same volunteer display a heterogeneity which is repeatable over a period of months. However, results also indicate that the lack of accurate quantitation of optical parameters and limited morphological information limits the ability to characterize different types of lesions and distinguish benign from malignant tissues. Drawbacks of our current methodology and plans for overcoming them are discussed.
一种时间分辨光学断层扫描系统已被用于生成人类乳房的横截面图像。图像通过迭代非线性算法以及相对于在均匀参考体模上采集的测量值的平均光子飞行时间测量值进行重建。已对三名健康志愿者和21名患有包括癌症在内的各种乳腺病变的患者进行了38项研究。我们已成功检测出19个病变中的17个，并表明同一志愿者健康乳房的光学图像显示出一种在数月内可重复的异质性。然而，结果也表明，光学参数缺乏准确的定量以及形态学信息有限，限制了表征不同类型病变以及区分良性和恶性组织的能力。讨论了我们当前方法的缺点以及克服这些缺点的计划。
