Kaneshiro Bliss E K, Acoba Jared D, Holzman Jennifer, Wachi Kelly, Carney Michael E
Department of Obstetrics and Gynecology, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Am J Obstet Gynecol. 2005 May;192(5):1452-4. doi: 10.1016/j.ajog.2004.12.078.
This study was undertaken to determine the (1) impact of delivery route on the natural history of cervical dysplasia and (2) overall regression rates of cervical dysplasia in pregnant women.
A retrospective analysis was performed on 705 pregnant women with abnormal Papanicolaou tests who presented for prenatal care at the Kapiolani Medical Center Women's Clinic in Honolulu, Hawaii, between 1991 and 2001. Data collection included demographics, delivery route, and cervical pathology.
Two hundred one patients met the inclusion criteria. Regression rates for vaginal and cesarean section groups were as follows: atypical squamous cells (64% vs 70%, P = .32), low-grade squamous intraepithelial lesion (58% vs 42%, P = .073), and high-grade squamous intraepithelial lesion (53% vs 25%, P = .44). Of the total population, 30% of lesions persisted postpartum, 58% regressed, and 12% progressed.
Mode of delivery does not influence the natural history of dysplastic lesions. Gravid and nongravid women have similar regression rates.
本研究旨在确定（1）分娩方式对宫颈发育异常自然病程的影响，以及（2）孕妇宫颈发育异常的总体消退率。
对1991年至2001年间在夏威夷檀香山卡皮奥拉尼医疗中心妇女诊所接受产前检查的705例巴氏试验异常的孕妇进行回顾性分析。数据收集包括人口统计学资料、分娩方式和宫颈病理情况。
201例患者符合纳入标准。阴道分娩组和剖宫产组的消退率如下：非典型鳞状细胞（64%对70%，P = 0.32）、低度鳞状上皮内病变（58%对42%，P = 0.073）和高度鳞状上皮内病变（53%对25%，P = 0.44）。在总人群中，30%的病变在产后持续存在，58%消退，12%进展。
分娩方式不影响发育异常病变的自然病程。妊娠和非妊娠女性的消退率相似。
