ICICT/ENSP - Fundação Oswaldo Cruz - FIOCRUZ, Biblioteca de Manguinhos suite 229, Av, Brasil 4365, Rio de Janeiro RJ 21045-900, Brazil.
BMC Infect Dis. 2013 Dec 1;13:564. doi: 10.1186/1471-2334-13-564.
HPV persistence is a key determinant of cervical carcinogenesis. The influence of postpartum on HPV clearance has been debated. This study aimed to assess HPV clearance in later pregnancy and postpartum among HIV-positive and negative women.
We conducted a follow-up study with 151 HPV-positive women coinfected with HIV, in 2007-2010. After baseline assessment, all women were retested for HPV infection using PCR in later pregnancy and after delivery. Multivariable logistic regressions assessed the putative association of covariates with HPV status in between each one of the successive visits.
Seventy-one women (47%) have eliminated HPV between the baseline visit and their second or third visits. HIV-positive women took a significantly longer time (7.0 ± 3.8 months) to clear HPV, compared to those not infected by HIV (5.9 ± 3.0 months). HPV clearance was significantly more likely to take place after delivery than during pregnancy (84.5% x 15.5%).
Both HIV-positive and negative women presented a significant reduction in HPV infection during the postpartum period. HIV-positive status was found to be associated with a longer period of time to clear HPV infection in pregnant women.
HPV 持续感染是宫颈癌发生的关键决定因素。产后对 HPV 清除的影响一直存在争议。本研究旨在评估 HIV 阳性和阴性妇女在妊娠晚期和产后 HPV 清除情况。
我们于 2007-2010 年对 151 名 HIV 合并 HPV 感染的女性进行了随访研究。基线评估后，所有女性均采用 PCR 法在妊娠晚期和产后再次检测 HPV 感染。多变量逻辑回归分析评估了各次随访之间 HPV 状态与协变量之间的潜在关联。
71 名女性（47%）在基线检查和第二次或第三次检查之间清除了 HPV。与未感染 HIV 的女性相比，HIV 阳性的女性清除 HPV 的时间明显更长（7.0±3.8 个月比 5.9±3.0 个月）。与妊娠期间相比，产后 HPV 清除的可能性明显更高（84.5%比 15.5%）。
HIV 阳性和阴性的女性在产后期间均显著降低了 HPV 感染。研究发现，HIV 阳性状态与妊娠妇女 HPV 感染清除时间延长有关。
