Kiguchi K, Bibbo M, Hasegawa T, Kurihara S, Tsutsui F, Wied G L
J Reprod Med. 1981 Feb;26(2):66-72.
To clarify the characteristics of dysplasia in the pregnant state, 525 of 703 dysplasias in pregnant women recorded in the laboratory computer at the University of Chicago Lying-in Hospital during a ten-year period were selected for study through medical records. These materials were basically diagnosed by cytologic techniques. The regression rates of moderate and marked dysplasia within a six-month period after delivery seemed to be much higher than those of dysplasia in the general population. The progression rates of dysplasia to carcinoma in situ during pregnancy and after delivery were almost the same as those of dysplasia in the nonpregnant state, whereas the progression rate of dysplasia to invasive carcinoma after delivery (0.4%) was almost half that in the nonpregnant state (1%). With reference to the latent period during which dysplasia progressed to malignancy, dysplastic lesions during pregnancy, as compared to those in nongravid women, had a higher potential for progression. The number of dysplastic cells decreased with the course of pregnancy. The rates of metaplastic and keratinizing types of dysplasia were remarkably higher than those in the general population, and the rates of those types of dysplasias increased with the course of pregnancy.
为明确孕期发育异常的特征，在十年期间于芝加哥大学妇产医院实验室电脑记录的703例孕妇发育异常病例中，选取了525例通过病历进行研究。这些材料基本通过细胞学技术诊断。产后六个月内中度和重度发育异常的消退率似乎远高于一般人群中的发育异常消退率。孕期及产后发育异常进展为原位癌的发生率与非孕期发育异常的发生率几乎相同，而产后发育异常进展为浸润癌的发生率（0.4%）几乎是非孕期（1%）的一半。关于发育异常进展为恶性肿瘤的潜伏期，与未孕女性相比，孕期的发育异常病变进展可能性更高。发育异常细胞数量随孕期进展而减少。化生型和角化型发育异常的发生率显著高于一般人群，且这些类型发育异常的发生率随孕期进展而增加。
