Epstein Lee B, Graham Carol A, Heit Michael H
Louisville Pelvic Floor Research Group, 4121 Dutchmans Lane, Suite 515, Louisville, KY 40207, USA.
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jul;19(7):1013-8. doi: 10.1007/s00192-007-0551-1. Epub 2008 Jan 24.
The objective of this study was to determine if vaginal stiffness index, an in vivo vaginal biomechanical property, is correlated with pelvic floor disorder symptom distress, impact on quality of life, or sexual function as measured by disease-specific quality-of-life scales. Forty-eight women completed validated quality-of-life scales (pelvic floor distress inventory-short form, pelvic floor impact questionnaire, and pelvic organ prolapse/urinary incontinence sexual questionnaire) and underwent in vivo vaginal biomechanical testing. After bivariate relationships between vaginal stiffness index and demographic, obstetric, and gynecologic variables were explored, multiple linear regression controlling for pelvic organ prolapse quantitative (POP-Q) stage of prolapse was performed. The vaginal stiffness index was inversely correlated with pelvic organ prolapse distress severity (POPDI-6) after controlling for POP-Q stage of prolapse (p = 0.011, r = 0.67, r (2) = 0.450, beta = -2.3). These findings provide initial evidence for the construct validity of in vivo vaginal biomechanical testing for pelvic organ prolapse evaluation because an increasing vaginal stiffness index is correlated with decreasing symptomatic and anatomic severity of disease.
本研究的目的是确定阴道硬度指数（一种体内阴道生物力学特性）是否与盆底功能障碍症状困扰、对生活质量的影响或通过疾病特异性生活质量量表测量的性功能相关。48名女性完成了经过验证的生活质量量表（盆底困扰量表简表、盆底影响问卷和盆腔器官脱垂/尿失禁性功能问卷），并接受了体内阴道生物力学测试。在探索阴道硬度指数与人口统计学、产科和妇科变量之间的双变量关系后，进行了控制盆腔器官脱垂定量（POP-Q）脱垂分期的多元线性回归。在控制脱垂的POP-Q分期后，阴道硬度指数与盆腔器官脱垂困扰严重程度（POPDI-6）呈负相关（p = 0.011，r = 0.67，r（2）= 0.450，β = -2.3）。这些发现为体内阴道生物力学测试用于盆腔器官脱垂评估的结构效度提供了初步证据，因为阴道硬度指数增加与疾病的症状和解剖严重程度降低相关。
