2'-脱氧-3'-硫代胞苷（BCH 189）的分离对映体在体外均能抑制人类免疫缺陷病毒的复制。
The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.
作者信息
Coates J A, Cammack N, Jenkinson H J, Mutton I M, Pearson B A, Storer R, Cameron J M, Penn C R
机构信息
Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1992 Jan;36(1):202-5. doi: 10.1128/AAC.36.1.202.
Abstract
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.
摘要
消旋2'-脱氧-3'-硫代胞苷（BCH 189）是一种双脱氧胞苷类似物，其中3'位碳原子被硫原子取代。BCH 189的对映体已被拆分，发现它们对1型和2型人类免疫缺陷病毒具有同等的抗病毒活性。然而，（-）-对映体（3TC）的细胞毒性明显低于（+）-对映体。
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