Olgyai Gábor, Haulik László, Oláh Attila
Petz Aladár Megyei Oktató Kórház, Sebészeti Osztály, Gyor.
Magy Seb. 2004 Oct;57(5):287-9.
Reports of synchronous or metachronous double kidney-pancreas cancers are very rare. Authors present the history of a 72-year-old woman who had a 10 kg loss of weight and epigastric pain. A complete gastroenterological check-up was carried out: kidney and synchronous pancreatic body cancer were found. The patient underwent distal pancreatectomy, splenectomy and nephrectomy with a worthwhile outcome. After an uneventful postoperative period the patient was discharged in good condition. Histology verified primary pancreatic ductal adenocarcinoma with synchronous primary renal clear cell carcinoma. The patient received oncotherapy and was well at 6 months' follow up. The appearance of different primaries in an individual may indicate a genetic predisposition to different neoplasms. In the literature there are some studies of double primary cancers, they are important because it might provide understanding of a shared genetic basis of different solid tumors. The association between these two cancers demands more detailed epidemiological and molecular investigation.
关于同时性或异时性双肾-胰腺癌的报道非常罕见。作者介绍了一位72岁女性的病史,该女性体重减轻了10公斤且上腹部疼痛。进行了全面的胃肠检查:发现了肾脏和同时存在的胰体癌。患者接受了远端胰腺切除术、脾切除术和肾切除术,结果良好。术后恢复顺利,患者状况良好出院。组织学证实为原发性胰腺导管腺癌合并同时性原发性肾透明细胞癌。患者接受了肿瘤治疗,随访6个月时情况良好。个体中出现不同的原发性肿瘤可能表明对不同肿瘤有遗传易感性。文献中有一些关于双原发性癌症的研究,它们很重要,因为这可能有助于理解不同实体瘤的共同遗传基础。这两种癌症之间的关联需要更详细的流行病学和分子研究。