胰腺癌合并第二原发性肾细胞癌患者的双重切除术
Double resection for patients with pancreatic cancer and a second primary renal cell cancer.
作者信息
Alexakis N, Bosonnet L, Connor S, Ellis I, Sutton R, Campbell F, Hughes M, Garvey C, Neoptolemos J P
机构信息
Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK.
出版信息
Dig Surg. 2003;20(5):428-32. doi: 10.1159/000072711. Epub 2003 Jul 31.
BACKGROUND
Reports of synchronous or metachronous double kidney-pancreas cancers are very rare.
METHODS
We present 2 patients with renal cell carcinoma and synchronous (1 patient) or metachronous (1 patient) primary pancreatic ductal adenocarcinoma. The patients underwent resection for both cancer types with a worthwhile outcome.
RESULTS
The appearance of different primaries in an individual may indicate a genetic predisposition to different neoplasms. The study of double primary cancers is important because it might provide understanding of a shared genetic basis of different solid tumors.
CONCLUSIONS
The association between these two cancers demands more detailed epidemiological and molecular investigation. From a clinical viewpoint a resectional policy is recommended.
背景
同步或异时性双肾-胰腺癌的报道非常罕见。
方法
我们报告2例肾细胞癌患者，其中1例为同步性（1例患者）或异时性（1例患者）原发性胰腺导管腺癌。这2例患者均接受了两种癌症的切除手术，结果令人满意。
结果
个体中出现不同的原发性肿瘤可能表明对不同肿瘤有遗传易感性。对双原发性癌症的研究很重要，因为它可能有助于理解不同实体瘤的共同遗传基础。
结论
这两种癌症之间的关联需要更详细的流行病学和分子研究。从临床角度来看，建议采取手术切除策略。
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