de Bruin Eveline A, Hulshoff Pol Hilleke E, Schnack Hugo G, Janssen Joost, Bijl Suzanne, Evans Alan C, Kenemans J Leon, Kahn René S, Verbaten Marinus N
Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Neuroimage. 2005 Jun;26(2):536-45. doi: 10.1016/j.neuroimage.2005.01.036.
The purpose of this study was to investigate whether current or lifetime alcohol intake is related to focal gray and white matter in healthy non-alcohol-dependent drinkers, and, if so, whether these densities are related to functional brain activity associated with visual attention. Voxel-based morphometric analyses of gray- and white-matter densities, and event-related potentials in response to a visual-attention task were determined in 47 male drinkers (current alcohol intake 20 drinks per week, lifetime alcohol intake 240 kg) and 44 female drinkers (current alcohol intake 15 drinks per week, lifetime alcohol intake 170 kg). All participants had a negative personal and family history of alcohol dependence to reduce possible confounding by genetic factors related to alcohol dependence. In males, mean lifetime alcohol intake was negatively associated with gray-matter density and positively associated with white-matter density in the right frontal gyrus (BA 6) and the right parietal region (BA 40). Right frontal (but not right parietal) gray and white matter in males correlated with the P3 amplitude of the event-related potentials elicited in a visual-attention task. In females, mean lifetime alcohol intake was not associated with gray- or white-matter density. Current alcohol intake was unrelated to gray or white matter in both males and females. In conclusion, lifetime alcohol intake is associated with focal gray-matter decreases and white-matter increases in the right frontal and right parietal brain regions in non-alcohol-dependent males, but not in females. These alcohol-related differences in focal brain matter in males are associated with differences in brain function related to visual attention. As the confounding effects of genetic factors were reduced, the present results may selectively relate to the effects of alcohol intake on focal brain matter.
本研究的目的是调查当前或终生饮酒量是否与健康的非酒精依赖饮酒者的局灶性灰质和白质有关，如果有关，这些密度是否与视觉注意力相关的脑功能活动有关。对47名男性饮酒者（当前每周饮酒量为20杯，终生饮酒量为240千克）和44名女性饮酒者（当前每周饮酒量为15杯，终生饮酒量为170千克）进行了基于体素的灰质和白质密度形态学分析，以及对视觉注意力任务的事件相关电位测定。所有参与者均有酒精依赖的阴性个人和家族史，以减少与酒精依赖相关的遗传因素可能造成的混杂影响。在男性中，终生平均饮酒量与右侧额下回（BA 6）和右侧顶叶区域（BA 40）的灰质密度呈负相关，与白质密度呈正相关。男性右侧额叶（而非右侧顶叶）的灰质和白质与视觉注意力任务中诱发的事件相关电位的P3波幅相关。在女性中，终生平均饮酒量与灰质或白质密度无关。当前饮酒量在男性和女性中均与灰质或白质无关。总之，终生饮酒量与非酒精依赖男性右侧额叶和右侧顶叶脑区的局灶性灰质减少和白质增加有关，但与女性无关。男性中这些与酒精相关的局灶性脑物质差异与视觉注意力相关的脑功能差异有关。由于遗传因素的混杂影响降低，目前的结果可能与饮酒量对局灶性脑物质的影响有选择性关联。
